| 10/23 | Blue/White Scrimmage | W,75-53 |
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| 11/03 | Pfeiffer (Exhibition) | W,112-27 | Duke Thrashes Pfeiffer
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| 11/06 | Lander (Exhibition) | W,79-52 | Duke Pushes Past Lander
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| Date | Opponent | Result | Our Coverage |
| 11/11 | at BYU | W,61-55 | Devils Survive BYU
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| 11/18 | Auburn | W,73-50 | Devils Knock Off Auburn
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| 11/20 | at Western Kentucky | W,80-54 | Sloppy Devils Top WKU
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| 11/25 | vs. Gardner-Webb | W,97-31 | Devils Dominate Gardner-Webb
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| 11/26 | vs. Notre Dame | L,54-56 | Irish Rally to Down Duke
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| 12/01 | Purdue | W,64-53 | Devils Power Past Purdue
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| 12/04 | Pittsburgh | W,92-43 | Duke Pummels Pitt
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| 12/08 | at Kentucky | L,65-72 | Kentucky Claws Duke
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| 12/11 | USC Upstate | W,93-35 | Duke Spanks Upstate Spartans
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| 12/20 | UNC Wilmington | W,107-45 | Devils Prey on Seahawks
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| 12/30 | at Temple | W,65-54 | Duke Outlasts Temple
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| 1/02 | Virginia | W,77-66 | Devils Shoot Past Virginia
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| 1/06 | at Wake Forest | W,76-58 | Duke Blocks Wake Forest
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| 1/08 | N.C. State | W,83-59 | Duke Runs Surpass Wolfpack
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| 1/13 | Florida State | W,73-66 | Devils Take Down FSU
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| 1/15 | at Virginia Tech | W,61-34 | Duke Handles the Hokies
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| 1/18 | at Georgia Tech | W,79-62 | Accurate Devils Down Jackets
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| 1/22 | Maryland | W,80-72 | Devils Take Down Terps
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| 1/27 | at Clemson | W,81-37 | Duke Smashes Clemson
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| 1/30 | Connecticut | L,45-61 | UConn D Stifles Duke
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| 2/02 | Wake Forest | W,75-43 | Devils Bounce Wake Forest
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| 2/06 | North Carolina | W,96-56 | Balanced Devils Thrash Heels by 40
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| 2/09 | at Boston College | W,71-62 | Chelsea Closes Out Boston College
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| 2/12 | at Florida State | W,67-57 | Duke Fends Off FSU
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| 2/15 | Virginia Tech | W,67-45 | Devils Outslug Virginia Tech
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| 2/19 | at Maryland | L,61-63 | Terps Slip Past Duke
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| 2/24 | Miami | W,74-64 | Devils Knock Off Canes
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| 2/26 | at North Carolina | W,69-63 | Duke Escapes the Tar Heels
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| 2012 Women's ACC Tournament |
| 3/02 | vs. NC State | L,72-75 | ACC QF: #9 NCSU Upsets Duke
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| 2012 Women's NCAA Tournament |
| 3/18 | vs. Samford | W,82-47 | NCAA: Duke Dominates Samford
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| 3/20 | vs. Vanderbilt | W,96-80 | NCAA: Duke Rolls Over Vandy
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| 3/24 | vs. St. John's | W,74-47 | NCAA: Devils Storm Past St. John's
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| 3/26 | vs. Stanford | L,81-69 | NCAA: Stanford Takes Out Duke
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